I recently purchased GHB tablets from B. Mougious and Co. and got a
portuguese product called GAMIBETAL. Now the portuguese insert says that
this is "Acido gama-amino-beta-hidroxibutirico" is this the same as
gamma-hydroxy-butyric-acid? What does amino-beta mean? I wonder if this
is just plain GABA instead because it’s very weak. Each tablet contains
250 mg of the active ingredient and taking 10 tabs feels *nothing* like
taking 2.5 grams of the real thing, which I used to have in powdered form
a long, long time ago….
thanks,
Michael
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DE DIGITALE STAD
Op 16 Aug 1995, Michael Ferrini schreef:
> I recently purchased GHB tablets from B. Mougious and Co. and got a
> portuguese product called GAMIBETAL. Now the portuguese insert says that
> this is "Acido gama-amino-beta-hidroxibutirico" is this the same as
> gamma-hydroxy-butyric-acid? What does amino-beta mean? I wonder if this
> is just plain GABA instead because it’s very weak. Each tablet contains
> 250 mg of the active ingredient and taking 10 tabs feels *nothing* like
> taking 2.5 grams of the real thing, which I used to have in powdered form
> a long, long time ago….
> thanks,
> Michael
Odd, the compound you mentioned seems to bear no resemblance with gamma
butyric acid (GHB or GBA).
this is GABA H2N-CH2-CH2-CH2-COOH
this is GBA HO-CH2-CH2-CH2-COOH (sodium salt= sodium oxybate)
this is GAMIBETAL H2N-CH2-CH -CH2-COOH (according to your data)
|
OH
(if gamma-beta-alpha-COOH)
It seems to me, you are in troubles.
Best regards (for those chemically interested: I have got the synthesis
of GBA from the lactone. If there is interest enough than I will post it.
Let me know personally -*do not spoil this newsgroup with "me toos"*- by
e-mailing a "me too/ GBA". Some motivation would be welcome. My altruism
will expire on friday next week. I have got similar "how toos"
for chromiumpicolinate "me too/ Cr" and the purification of ethoxyquin
"me too/ EtQ"). Information is meant to be for personal use and at your
own risk.
Best regards,
drs Angelo Schouten
(Chem/Phys/ Sci life extension, Sci med nutrition, F the Feds)
My guess:
C-Calpha-Cbeta-Cgamma
GHB == gamma-hydroxybutericacid ==
HOOC-Ca-Cb-C-OH
> Acido gama-amino-beta-hidroxibutirico
HOOC-Ca-COH-CNH2
So that would make up for something completely different …
A Friendly Chemist
In article <40u541$…@panix2.panix.com>,
Michael Ferrini (rang…@panix.com) writes:
>I recently purchased GHB tablets from B. Mougious and Co. and got a
>portuguese product called GAMIBETAL. Now the portuguese insert says that
>this is "Acido gama-amino-beta-hidroxibutirico" is this the same as
>gamma-hydroxy-butyric-acid? What does amino-beta mean?
It should be gamma-amino-beta-hydroxybutyric acid, which is
different from GABA and GHB. Ask for a refund.
—————————————————————–
Steven Wm. Fowkes (fow…@ceri.win.net) voice: 415-321-CERI
Cognitive Enhancement Research Institute fax: 415-323-3864
PO Box 4029, Menlo Park, CA 94026 USA alt: 415-321-6670
—————————————————————–
I don’t know if you got the proper thing or not, but I do have a list of
over seas providers of the "REAL" thing. I haven’t faxed them yet for a
price list but if you want to do the fax and post me prices, I will send
the list.
— ———————————————————-
DE DIGITALE STAD
Op Mon, 28 Aug 1995, Paul Walsh schreef:
> In alt.psychoactives you write:
> >Let me know personally -*do not spoil this newsgroup with "me toos"*- by
> >e-mailing a "me too/ GBA". Some motivation would be welcome. My altruism
>
> —
> —
OK dudes and dudettes. You will find my file in sci.life-extension
(Posted late thursday). Read
the disclaimer beforehand. I have had many undergraduate students and
even postdocs who were able to mess up even the simplest things. Be
advised though!
I have tried to make it even more clear. As such you
will find some toxicology and experimental settings. The actual synthesis
is accurately type over.
Remember, adding sodiumhydroxide (NaOH) to water leads to heat-effects.
Since the lactone is volatile, you are advised to add NaOH *GRADUALLY*. Some
initial cooling (before refluxing) would be a very wise decision.
Remember there are more ways to synthesize GHB, I have taken the best and
cleanest route. For the more experienced (academic or laboratory worker)
there is a way (I can think of by retro-synthesis) to make it from GABA (but
your own body does it for you)
or Glutamate. The latter option is an full scale synthesis, with many
unpleasant steps (reagents, solvents, conditions). I can hardly recommend
that. The lactone-opening is the very best I can think of.
Best regards,
Angelo, live longer and prosperous
In article <41nl72$…@newsbf02.news.aol.com> elf…@aol.com (Elfism) writes:
> I don’t know if you got the proper thing or not, but I do have a list of
> over seas providers of the "REAL" thing. I haven’t faxed them yet for a
> price list but if you want to do the fax and post me prices, I will send
> the list.
I would like to see this list. How about posting the it.
_______________________________________________________________________________
Don Steiger D…@mumathnx4.cs.missouri.edu
_______________________________________________________________________________
REPOSTed in alt.psychoactives, not sci-life-extension, no Gremlins.
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DE DIGITALE STAD
In <Pine.SUN.3.90.950828152952.27095A-100…@dds.dds.nl> Angelo
- Hide quoted text — Show quoted text -
Schouten <d_qu…@dds.nl> writes:
>— ———————————————————-
> DE DIGITALE STAD
>Op Mon, 28 Aug 1995, Paul Walsh schreef:
>> In alt.psychoactives you write:
>> >Let me know personally -*do not spoil this newsgroup with "me
toos"*- by
>> >e-mailing a "me too/ GBA". Some motivation would be welcome. My
altruism
>>
>> —
>> —
>OK dudes and dudettes. You will find my file in sci.life-extension
>(Posted late thursday). Read
>the disclaimer beforehand. I have had many undergraduate students and
>even postdocs who were able to mess up even the simplest things. Be
>advised though!
>I have tried to make it even more clear. As such you
>will find some toxicology and experimental settings. The actual
synthesis
>is accurately type over.
>Remember, adding sodiumhydroxide (NaOH) to water leads to
heat-effects.
>Since the lactone is volatile, you are advised to add NaOH
*GRADUALLY*. Some
>initial cooling (before refluxing) would be a very wise decision.
>Remember there are more ways to synthesize GHB, I have taken the best
and
>cleanest route. For the more experienced (academic or laboratory
worker)
>there is a way (I can think of by retro-synthesis) to make it from
GABA (but
>your own body does it for you)
>or Glutamate. The latter option is an full scale synthesis, with many
>unpleasant steps (reagents, solvents, conditions). I can hardly
recommend
>that. The lactone-opening is the very best I can think of.
>Best regards,
>Angelo, live longer and prosperous
Angelo, you don’t have to boil or reflux this stuff. You just have to
let it sit at room temp for a while, and the lactone cleaves fine (or
so I’m told). No messy or fancy glassware needed.
Steve Harris, M.D.
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DE DIGITALE STAD
Op Sun, 3 Sep 1995, Koh Theng Tat Sam schreef:
> hi there,
> sorry to be sending u personal mail, but i have some
> question to ask you, i readsome of ur replies to dr proctor,
> my question is that : is his hair-product – (proxiphen), any good
> its supposed to contain spirolactone, minoxidil, tretinoin, etc
> thanks
> —
> Regards,
> Sam
I am not an expert on hair, even though I’ve got plenty of it. But I
have knowledge about the minoxidil and tretinoin. Peter Proctor
commented earlier on minox. (hair growth- and NO agonist). Minox. is a
approved (FDA?) hairgrowth agent (and between you and me -a topical applied
"aphrodisiac"/ see my original reference posting on "Yohimbine, Minoxidil
and NO .."). Tretinoin (0.025-0.05%)is capable of regrowing hair too
(including! damaged inner-ear hair -in ear pathology).
My concern about tret. is
directed to its anti-tumor properties .. and skin renewal.
I have made some tret. ointments myself. Tret. is relatively irritant but
its effect on skin is remarkable. I am using it now for 2 years in a row.
I have to wait till I grow old to see if the result is really awesome.
Peter also pattented the use of topical TEMPO(L) (again a molecule
bearing the NO moiety) in regrowing hair. Seems to be promising and of
low order toxicity.
Nevertheless all of the former agents are rather experimental. It is up
to you -the responsible individual- to decide what is best for you and to
my humble opinion no government -or medical establishment- has the right to
deny this right to you.
Best regards,
Angelo
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DE DIGITALE STAD
Op 2 Sep 1995, Steven B. Harris schreef:
> Angelo, you don’t have to boil or reflux this stuff. You just have to
> let it sit at room temp for a while, and the lactone cleaves fine (or
> so I’m told). No messy or fancy glassware needed.
> Steve Harris, M.D.
Steve you are right -but it needs to run to completion (even though it
comprises a strong base like NaOH). This is done by
heating it. Also the salt precipitates, so at roomtemperature you will
get crystals of the salt making it hard to get at the rest of the lactone.
I never rely on what "I’m told". Things are too tricky. So stick to the
recipe. The experienced chemical worker will have another look at the
Chemical Abstracts to look for other syntheses. But some of the readers -I
assume- are not that experienced. And er I do not think the glass
mentioned is fancy or messy, it is simply standard. With a little fantasy
you can make a replacement for the glass refluxer (i.g. stainless-steel
tubes). But this is all I want to say about it. Enjoy and be careful.
Best regards,
Angelo Schouten